Responsa for Eruvin 129:1

יכול אני לפטור את כל העולם כולו מן הדין מיום שחרב בית המקדש ועד עכשיו שנאמר (ישעיהו נא, כא) לכן שמעי נא זאת ענייה ושכורת ולא מיין

I could justify the exemption from judgment of all the [Israelite] world since the day of the destruction of the Temple until the present time, for it is said in Scripture: Therefore hear now this, thou afflicted and drunken but not with wine.<span class="x" onmousemove="('comment',' Isa. LI, 21. Having been described as 'drunken' prior to the destruction of the Temple, Israel, still bearing the stigma, cannot be held responsible for their actions.');">¹</span> An objection was raised: The sale or purchase of an intoxicated person is valid. If he committed a transgression involving the penalty of death he is to be executed, and if he committed one involving flogging he is to be flogged; the general rule being that he is regarded as a sober man in all respects except that he is exempt front prayer.<span class="x" onmousemove="('comment',' Tosef. Ter. III.');">²</span> [Does not this<span class="x" onmousemove="('comment',' The ruling that, with the exception of the duty of prayer, all intoxicated man is in all respects regarded as a sober man.');">³</span>

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