Quoting%20commentary for Makkot 37:10

וכי דבר הלמד בהקש חוזר ומלמד בהקש מעשר דגן חולין הוא

But can something derived through a hekesh proceed to teach something else through a hekesh? Maaser of wheat is a non-sanctified item [and thus not subject to the two-hekesh rule].

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