Reference for Berakhot 44:17

היה מתפלל ומצא צואה במקומו אמר רבה אע"פ שחטא תפלתו תפלה מתקיף ליה רבא והא (משלי כא, כז) זבח רשעים תועבה אלא אמר רבא הואיל וחטא אע"פ שהתפלל תפלתו תועבה:

If a man was reciting the Tefillah and found excrement where he was standing, Rabbah said : Even if he himself was responsible for it, his Tefillah is valid. Raba retorted : But lo [it is written], "The sacrifice of the wicked is an abomination" (Prov. xxi. 27)! Therefore, said Raba, since he is responsible [for the excrement], although he has uttered the prayer, his Tefillah is an abomination.

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