Reference for Pesachim 40:16

ומשני שאני התם דאיכא הפסד חולין

But the following contradicts it: If a cask of [wine of clean] terumah is broken in the upper vat, while [in] the lower there is unclean hullin: R'Eliezer and R'Joshua agree that if a rebi'ith thereof can be saved i purity, one must save it. But if not, - R'Eliezer ruled: Let it descend and be defiled, yet let him not defile with [his own] hands; R'Joshua said: He may even defile it with his own hands? - And he answer ed: There it is different, because there is the loss of hullin.

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