Commentary for Berakhot 12:22
אמר ליה אלו דברים שעומדים ברומו של עולם ובני אדם מזלזלין בהן
He answered : This refers to the things that stand in the height [rum] of the world which are despised by men.
Abraham Cohen Footnotes to the English Translation of Masechet Berakhot
E.g. prayer which ascends to God.
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