Responsa for Berakhot 108:14
הולכי מדברות מנלן דכתיב תעו במדבר בישימון דרך עיר מושב לא מצאו ויצעקו אל ה' וידריכם בדרך ישרה יודו לה' חסדו
"They who journey in the desert" — whence have we this ? For it is written, "They wandered in the wilderness in a desert way ; they found no city of habitation...Then they cried unto the Lord... and He led them by a straight way... Let them give thanks unto the Lord for His mercy" (ibid. vv. 4-8).
Shut min haShamayim
They responded to the first question: "Lift your hands to the sacred!" (Psalms 134:2) Namely, wash your hands whenever you want to speak sacred words or study Torah. "And bless God!" (ibid.) - with the blessing instituted for washing hands. As for the second question, they responded: Do you not know that four need to give thanks (Berachot 54b:12), and this includes one who was sick. And none are more sick than such a person [who relieves themself], as it says (Isaiah 51:14): "Quickly the crouching one is freed."2cf. Rashi on Isaiah 51:14
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